BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Supplemental material This content has been supplied by the author(s). Provenance and peer review Not commissioned internally peer reviewed. Patient consent for publication Not required.Įthics approval This study was approved by the institutional review board of Severance Hospital (4-2016-0901). All authors reviewed and approved the final version of the manuscript.įunding This research was supported by a faculty research grant of Yonsei University College of Medicine (6-2019-0184) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C1324). JJS and Y-BP contributed in data collection and revised the draft of the manuscript. JY and S-WL wrote the first draft of the manuscript. TY, SSA and S-WL collected and analyzed the data. Even though serum GrB could not reflect the inflammatory burden of AAV, serum GrB was associated with otorhinolaryngological, pulmonary, and renal involvement in immunosuppressive drug-naïve patients with AAV.Ĭontributors TY, JY and S-WL researched the literature and conceived the study. In addition, serum GrB was inversely correlated with the cross-sectional FFS (r=−0.249, p=0.028). On the other hand, patients with renal involvement showed a significantly lower serum GrB than those without (p=0.023). When serum GrB levels were compared after dividing the patients into two groups based on the presence of organ-specific involvement, patients with pulmonary involvement exhibited a significantly higher serum GrB than those without (p=0.042). Serum GrB was not associated with the cross-sectional BVAS however, patients with serum GrB positivity exhibited higher frequencies of otorhinolaryngological manifestation than those without (p=0.037).
![serum serial number not showing up serum serial number not showing up](https://wwwnc.cdc.gov/eid/images/18-1262-F1-tn.jpg)
The median age of patients with AAV was 62 years and 26 patients were men. AAV-specific indices included Birmingham Vasculitis Activity Score (BVAS) and Five-Factor Score (FFS). On the day of the blood sampling, we performed routine laboratory tests including antineutrophil cytoplasmic antibody tests and collected both clinical and laboratory data.
![serum serial number not showing up serum serial number not showing up](https://i.ytimg.com/vi/XgztfRBc2jM/maxresdefault.jpg)
At the time of the first classification, whole blood was obtained from each patient and sera was immediately isolated and stored at – 80℃. Seventy-eight immunosuppressive drug-naïve patients with AAV were included in this study. We investigated whether serum granzyme B (GrB) can reflect the inflammatory burden such as cross-sectional disease activity and organ-specific involvement in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV).